Log in Register
Menu

Anti-CD3, Recombinant [UCH-T1®]

Invented by Prof Peter Beverley at Imperial College

Info

Catalogue Number 152589
Applications FACS WB
Antigen/Gene or Protein Targets CD3
Reactivity Human
Relevance The CD3 complex, composed of five CD3 polypeptide chains, associates with the T cell antigen receptor (TCR) and is found on all mature human T lymphocytes. UCH-T1/UCHT1 is considered a pan T-cell marker - it can be used for the detection of T cell populations in peripheral blood and lymph nodes and the categorisation of T versus B cell lymphomas and leukaemias. It reacts with the majority of peripheral blood T lymphocytes, a major proportion of thymocytes, the majority of T cell chronic lymphocytic leukaemia cells, Sézary leukaemias and approximately 70% of acute lymphoblastic leukaemias of T cell origin. It can also be used to study the role of CD3 in TCR signal transduction events.
Host Mouse
Immunogen Human infant thymocytes and Sezary cells.
Subclass IgG1
Formulation PBS only
Concentration 1mg/ml
Research Area Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology
Notes Recommended for the enrichment of T cell populations by cell sorting or panning.

Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma.

References: 1 entry

Original hybridoma first published in: Beverley et al. 1981. Eur J Immunol. 11(4):329-34. PMID: 6788570.


Add a reference

References: 1 entry

Original hybridoma first published in: Beverley et al. 1981. Eur J Immunol. 11(4):329-34. PMID: 6788570.


Add a reference

References: 1 entry

Original hybridoma first published in: Beverley et al. 1981. Eur J Immunol. 11(4):329-34. PMID: 6788570.


Add a reference


This reagent does not have any reviews at the moment.