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Recombinant Antibodies

Anti-CD45RO, Recombinant [UCH-L1]

Invented by Prof Peter Beverley from Imperial College
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
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Catalogue Number 152588
Applications FACS IHC IP WB
Antigen/Gene or Protein Targets Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45RO)
Reactivity Human
Relevance PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple PTPRC isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumours. This antibody reacts with an epitope unique for CD45R0. It may identify abnormalities of functional T-cell subsets in immune disorders, be used in tumour diagnosis by FACS or immunohistology and has been very useful in studies of human T cell function and ontogeny.
Host Mouse
Immunogen Cultured T cells from an IL-2-dependent T-cell line (CA1) prepared from human peripheral blood activated with influenza virus.
Subclass IgG2a
Formulation PBS only
Concentration 1mg/ml
Molecular Weight (kDa) 180
Research Area Cancer, Cell Type or Organelle Marker, Epitope Tags, Immunology
Notes Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma.

References

There are 2 reference entries for this reagent.

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References: 2 entries

Original hybridoma first published in Smith et al. 1986. Immunology. 58(1):63-70. PMID: 2423439.

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Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.

Europe PMC ID: 2423439

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References: 2 entries

Original hybridoma first published in Smith et al. 1986. Immunology. 58(1):63-70. PMID: 2423439.

View  

Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.

View  

Add a reference

Inventor Information