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Recombinant Antibodies

Anti-HPV16E6 & HPV18E6, Recombinant [C1P5]

Invented by Dr Lawrence Banks from International Centre For Genetic Engineering And Biotechnology (ICGEB)
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
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Info

Catalogue Number 152582
Applications IHC IP WB
Antigen/Gene or Protein Targets Human Papilloma Virus-16 and 18 early protein 6 (HPV16E6 & HPV18 E6)
Reactivity Human
Relevance The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. C1P5 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
Host Mouse
Immunogen Gel-purified HPV-18 E6-beta galactosidase fusion protein
Subclass IgG1
Formulation PBS only
Concentration 1mg/ml
Research Area Cancer, Virology
Notes Reacts with HPV infected human cells

HPV-18: 15.8 kD; HPV-16: 17kDa

Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma.

References

There are 2 reference entries for this reagent.

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References: 2 entries

Original hybridoma first published in Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.

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Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.

Europe PMC ID: 3033140

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References: 2 entries

Original hybridoma first published in Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.

View  

Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.

View  

Add a reference

Inventor Information