Anti-ADAM19, Polyclonal [19MOCYT]
Invented by Prof Carl Blobel from Hospital For Special Surgery At Weill Cornell Medicine
Invented at
- Datasheet
- References (4)
- Inventor Info
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| Catalogue Number | 152534 |
| Applications | WB |
| Antigen/Gene or Protein Targets | ADAM19 |
| Reactivity | Mouse |
| Relevance | ADAM19, is a member of the ADAM (a disintegrin and metalloprotease-like domain) family. It has been cloned from mouse and human. ADAM19 was first described in muscle cells as a protein with homology to the fertilins (ADAMs 1 and 2). Initial observations indicated a role for ADAM19 in myoblast fusion, similar to sperm-egg fusion aided by ADAMs 1 and 2. Later works describe ADAM19 in the bone, muscle, lung, heart, brain, kidney, and a wide range of tissues. Also reported is a sequence of ADAM19 lacking the transmembrane and cytoplasmic domains, suggesting that a soluble form is produced. Other ADAMs family members (ADAM-10, ADAM-17) have been more thoroughly studied, and are known to play key roles in inflammation, growth factor maturation and release, and a wide range of other functions. |
| Host | Rabbit |
| Immunogen | GST-fusion protein with the cytoplasmic domain of murine ADAM19 |
| Formulation | Whole serum |
| Molecular Weight (kDa) | ~120 |
| Notes | Suggested dilution for western blot: 1:500 |
| Research Area | Cancer, Cell Signaling & Signal Transduction |
References: 4 entries
Chesneau et al. 2003. J Biol Chem. 278(25):22331-40. PMID: 12682046.
Inoue et al. 1998. J Biol Chem. 273(7):4180-7. PMID: 9461614.
Kawaguchi et al. 2007. J Cell Sci. 120(Pt 6):943-52. PMID: 17344430.
Zhou et al. 2004. Mol Cell Biol. 24(1):96-104. PMID: 14673146.
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References: 4 entries
Chesneau et al. 2003. J Biol Chem. 278(25):22331-40. PMID: 12682046.
Inoue et al. 1998. J Biol Chem. 273(7):4180-7. PMID: 9461614.
Kawaguchi et al. 2007. J Cell Sci. 120(Pt 6):943-52. PMID: 17344430.
Zhou et al. 2004. Mol Cell Biol. 24(1):96-104. PMID: 14673146.
Add a reference
