Anti-ADAM17, Polyclonal [17MOCYT]
Invented by Prof Carl Blobel from Hospital For Special Surgery At Weill Cornell Medicine
Invented at
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- References (5)
- Inventor Info
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| Catalogue Number | 152533 |
| Applications | WB |
| Antigen/Gene or Protein Targets | ADAM17 |
| Reactivity | Mouse |
| Relevance | ADAM17 (TACE/CD156b) has proved capable of cleaving epidermal growth factor receptor (EGFR) ligands, extracellular Notch1, cell-surface receptors, and adhesion molecules. As proteolytic cleavage is an indispensable activation event for many of these substrates, ADAM17 has emerged as an attractive therapeutic target for the treatment of cancer and rheumatoid arthritis. |
| Host | Rabbit |
| Immunogen | GST-cyto corresponding to the cytoplasmic domain of murine ADAM17 |
| Formulation | Whole serum |
| Molecular Weight (kDa) | ~100 (mature form), ~120 (pro-form) |
| Notes | Suggested dilution for western blot: 1:1000 |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Metabolism, Neurobiology, Stem Cell Biology |
References: 5 entries
Horiuchi et al. 2007. J Immunol. 179(5):2686-9. PMID: 17709479.
Le Gall et al. 2010. J Cell Sci. 123(Pt 22):3913-22. PMID: 20980382.
Maretzky et al. 2011. Nat Commun. 2:229. PMID: 21407195.
Schlöndorff et al. 2000. Biochem J. 347 Pt 1:131-8. PMID: 10727411.
Zheng et al. 2002. J Biol Chem. 277(45):42463-70. PMID: 12207026.
Add a reference
References: 5 entries
Horiuchi et al. 2007. J Immunol. 179(5):2686-9. PMID: 17709479.
Le Gall et al. 2010. J Cell Sci. 123(Pt 22):3913-22. PMID: 20980382.
Maretzky et al. 2011. Nat Commun. 2:229. PMID: 21407195.
Schlöndorff et al. 2000. Biochem J. 347 Pt 1:131-8. PMID: 10727411.
Zheng et al. 2002. J Biol Chem. 277(45):42463-70. PMID: 12207026.
Add a reference
