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Anti-mIL-17A [MM17F3]

Info

Applications ELISA Fn
Antigen/Gene or Protein Targets mIL-17A
Synonyms Interleukin 17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL-17A; CTLA8; IL17
Reactivity Virus
Relevance IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.
Host Mouse
Subclass IgG1
Research Area Virology

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