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Anti-TAF4 [32TA-2B9]

Info

Applications ELISA IF IP WB
Antigen/Gene or Protein Targets  TAF4 (formerly TAFII135) 
Reactivity Human and Mouse
Relevance TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF4 is one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases.
Host Mouse
Immunogen Synthetic peptide LAASAAHHHHLAPRTPEVRA corresponding to amino acids 33-52 of TAF4
Subclass IgG1 kappa
Notes Available in 100ul units

Recommended dilution: 1/500-1/5000
Research Area Epigenetics & Nuclear Signalling

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