Anti-TAF4 [32TA-2B9]
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| Applications | ELISA IF IP WB |
| Antigen/Gene or Protein Targets | TAF4 (formerly TAFII135) |
| Reactivity | Human and Mouse |
| Relevance | TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF4 is one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. |
| Host | Mouse |
| Immunogen | Synthetic peptide LAASAAHHHHLAPRTPEVRA corresponding to amino acids 33-52 of TAF4 |
| Subclass | IgG1 kappa |
| Notes |
Available in 100ul units Recommended dilution: 1/500-1/5000 |
| Research Area | Epigenetics & Nuclear Signalling |
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