Anti-Rxra [4RX-1D12]
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| Applications | ELISA |
| Antigen/Gene or Protein Targets | RXR alpha (Retinoid X receptor alpha) |
| Reactivity | Human and Mouse |
| Relevance | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. |
| Host | Mouse |
| Immunogen | Recombinant protein, epitope corresponding to DE‐region of mouse RXRa |
| Subclass | IgG1 kappa |
| Notes | Available in 100ul unit |
| Research Area | Epigenetics & Nuclear Signalling |
References: 2 entries
Bortell et al. 1993. Proc Natl Acad Sci U S A. 90(6):2300-4. PMID: 8460137.
Constitutive transcription of the osteocalcin gene in osteosarcoma cells is reflected by altered protein-DNA interactions at promoter regulatory elements.
Europe PMC ID: 8460137
Add a reference
References: 2 entries
Bortell et al. 1993. Proc Natl Acad Sci U S A. 90(6):2300-4. PMID: 8460137.
Constitutive transcription of the osteocalcin gene in osteosarcoma cells is reflected by altered protein-DNA interactions at promoter regulatory elements.
Europe PMC ID: 8460137
Add a reference
References: 2 entries
Bortell et al. 1993. Proc Natl Acad Sci U S A. 90(6):2300-4. PMID: 8460137.
Constitutive transcription of the osteocalcin gene in osteosarcoma cells is reflected by altered protein-DNA interactions at promoter regulatory elements.
Add a reference
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