Anti-POLR2E [2PB-4H7]
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Info
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | RNA Polymerase B Subunit hRPB5 |
| Reactivity | N/A |
| Relevance | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process. |
| Host | Mouse |
| Immunogen | Recombinant human hRPB5 protein. |
| Subclass | IgG1 kappa |
| Notes |
Available in 100ul unit as ascites. The hRPB5 protein is present in RNA polymerases I, II and III. |
| Research Area | Epigenetics & Nuclear Signalling |
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