Anti-Nsd1 [1NW-1A10]
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Info
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | NSD1 (Sotos Syndrome) |
| Reactivity | Mouse |
| Relevance |
KMT3B / NSD1 is a histone methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. Defects in NSD1 are the cause of Sotos syndrome (SOTOSS) [MIM:117550]; also known as cerebral gigantism. It is a disorder characterized by excessively rapid growth, acromegalic features, and a nonprogressive cerebral disorder with mental retardation. High-arched palate and prominent jaw are noted in several patients. Most cases of Sotos syndrome are sporadic and may represent new dominant mutation. |
| Host | Mouse |
| Immunogen | Recomb prot (738-891) |
| Subclass | IgG1 kappa |
| Notes |
Epitope localized between aa 738 and 891 Available in 100ul unit |
| Research Area | Epigenetics & Nuclear Signalling |
References: 1 entry
References: 1 entry
References: 1 entry
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