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Anti-Nsd1 [1NW-1A10]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  NSD1 (Sotos Syndrome) 
Reactivity Mouse
Relevance KMT3B / NSD1 is a histone methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.

Defects in NSD1 are the cause of Sotos syndrome (SOTOSS) [MIM:117550]; also known as cerebral gigantism. It is a disorder characterized by excessively rapid growth, acromegalic features, and a nonprogressive cerebral disorder with mental retardation. High-arched palate and prominent jaw are noted in several patients. Most cases of Sotos syndrome are sporadic and may represent new dominant mutation.
Host Mouse
Immunogen Recomb prot (738-891)
Subclass IgG1 kappa
Notes Epitope localized between aa 738 and 891

Available in 100ul unit
Research Area Epigenetics & Nuclear Signalling

References: 1 entry

Huang et al. 1998. EMBO J. 17(12):3398-412. PMID: 9628876.


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References: 1 entry

Huang et al. 1998. EMBO J. 17(12):3398-412. PMID: 9628876.


Add a reference

References: 1 entry

Huang et al. 1998. EMBO J. 17(12):3398-412. PMID: 9628876.


Add a reference


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