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Anti-Heterochromatin protein-1 beta [1MOD-1A9]

Info

Applications ELISA IHC IF WB
Antigen/Gene or Protein Targets  Heterochromatin Protein 1b (HP-1 b) 
Reactivity Human and Mouse
Relevance The anti‐Heterochromatin protein‐1 b, clone 1MOD‐1A9, is specific for Hp1b protein from mouse and human. The family of Heterochromatin Protein 1 (HP1) consists of highly conserved proteins, which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromeres, sequesteration of genes to nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at the single nucleosome level and gene repression by heterochromatization of euchromatin. In mammals there are three paralogs: HP1α, HP1β and HP1γ. HP1β interacts with the histone methyltransferase (HMTase) Suv(3-9)h1 and is a component of both pericentric and telomeric heterochromatin. HP1β is a dosage-dependent modifier of pericentric heterochromatin-induced silencing and silencing is thought to involve a dynamic association of the HP1β chromodomain with the tri-methylated Histone H3 Me(3)K9H3.
Host Mouse
Immunogen Recombinant mouse HP1 beta
Subclass IgG1 kappa
Notes Available in 100ul unit as ascites.

Recommended dilutions : 1/500 – 1/5000
Research Area Epigenetics & Nuclear Signalling

References: 1 entry

Nielsen et al. 1999. EMBO J. 18(22):6385-95. PMID: 10562550.


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References: 1 entry

Nielsen et al. 1999. EMBO J. 18(22):6385-95. PMID: 10562550.


Add a reference

References: 1 entry

Nielsen et al. 1999. EMBO J. 18(22):6385-95. PMID: 10562550.


Add a reference


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