- References (2)
- Inventor Info
|Applications||ELISA IHC IF WB|
|Antigen/Gene or Protein Targets||Heterochromatin Protein 1b (HP-1 b)|
|Reactivity||Human and Mouse|
|Relevance||The anti‐Heterochromatin protein‐1 b, clone 1MOD‐1A9, is specific for Hp1b protein from mouse and human. The family of Heterochromatin Protein 1 (HP1) consists of highly conserved proteins, which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromeres, sequesteration of genes to nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at the single nucleosome level and gene repression by heterochromatization of euchromatin. In mammals there are three paralogs: HP1α, HP1β and HP1γ. HP1β interacts with the histone methyltransferase (HMTase) Suv(3-9)h1 and is a component of both pericentric and telomeric heterochromatin. HP1β is a dosage-dependent modifier of pericentric heterochromatin-induced silencing and silencing is thought to involve a dynamic association of the HP1β chromodomain with the tri-methylated Histone H3 Me(3)K9H3.|
|Immunogen||Recombinant mouse HP1 beta|
Available in 100ul unit as ascites.
Recommended dilutions : 1/500 – 1/5000
|Research Area||Epigenetics & Nuclear Signalling|
There are 2 reference entries for this reagent.View All References
References: 2 entries
No inventors are currently linked to this reagent.
Add an inventor
Add an inventor