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Monoclonal Antibodies

Anti-TDP43 [DB9]

Invented by Dr Fiona Benson from Lancaster University
Invented at Lancaster University
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Catalogue Number 152054
Applications ELISA WB
Antigen/Gene or Protein Targets TDP43
Reactivity Human
Relevance Monoclonal antibody used in study of TDP-43 associated diseases.

Background and Research Application
TAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease.
Host Mouse
Immunogen A His-tagged recombinant protein corresponding to amino acid residues 208-414 of human TDP-43.
Immunogen UniProt ID Q13148
Subclass IgG1 kappa
Myeloma Used Sp2/0-Ag14
Notes Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Concentration
1mg/ml as standard
Research Area Epigenetics & Nuclear Signalling, Neurobiology, Virology

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