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Anti-CD40L [YMF 323.6.2]

Info

Applications FACS WB
Antigen/Gene or Protein Targets CD40L
Synonyms CD40 Ligand; TNF-Related Activation Protein; Tumor Necrosis Factor (Ligand) Superfamily Member; T-B Cell-Activating Molecule; T-Cell Antigen Gp39; TNFSF5; CD40-L; TRAP; Tumor Necrosis Factor Ligand Superfamily Member 5; Hyper-IgM Syndrome; CD154 Antigen; HCD40L; CD154; T-BAM; HIGM1; Gp39; IMD3; IGM
Reactivity Human
Relevance The CD40-CD40L interaction is an essential signal for B cell proliferation, expression of activation markers, immunoglobulin production and isotype switching. CD40-CD40L interaction is also required for formation of B memory cells and germinal centers, and signaling through CD40 prevents apoptosis of germinal center B cells. Defective expression of CD40L in humans leads to an inability to produce isotypes other than IgM (hyper IgM syndrome), and to an absence of germinal centers. More recent evidence indicates an expansion of the role of the CD40-CD40L axis in cellular interactions beyond antibody formation.
Host Rat
Immunogen CD40L
Subclass IgG2a
Research Area Cardiovascular, Cell Signaling & Signal Transduction, Immunology

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