Anti-CLEC9A [397]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 151704 |
| Applications | WB |
| Antigen/Gene or Protein Targets | Mouse DNGR1 |
| Synonyms | C-Type Lectin Domain Family 9 Member A; HEEE9341; UNQ9341; DNGR-1; CD370; DNGR1 |
| Reactivity | Mouse |
| Relevance | Recognises mouse DNGR-1, also known as CLEC9A, which is a highly specific marker of the CD8a+ and the CD103+ DC subsets, as well as a receptor able to recognise a preformed signal exposed on necrotic cells. |
| Host | Rat |
| Immunogen | RBL-2H3 cells expressing mouse DNGR-1 fused to an HA epitope |
| Positive Control | rat IgG2a isotype-matched control mAbs |
| Subclass | IgG2a |
| Myeloma Used | Y3.AG.1.2.3 |
| Recommended Growing Conditions | RPMI + 10% FCS + Pen + Strep + Glutamine + 2-ME |
| Research Area | Immunology, Stem Cell Biology |
References: 6 entries
Joffre et al. 2010. Eur J Immunol. 40(5):1255-65. PMID: 20333625.
Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A.
Europe PMC ID: 20333625
Sancho et al. 2009. Nature. 458(7240):899-903. PMID: 19219027.
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity.
Europe PMC ID: 19219027
Sancho et al. 2008. J Clin Invest. 118(6):2098-110. PMID: 18497879.
Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.
Europe PMC ID: 18497879
Add a reference
References: 6 entries
Joffre et al. 2010. Eur J Immunol. 40(5):1255-65. PMID: 20333625.
Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A.
Sancho et al. 2009. Nature. 458(7240):899-903. PMID: 19219027.
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity.
Sancho et al. 2008. J Clin Invest. 118(6):2098-110. PMID: 18497879.
Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.
Add a reference
