MUC1 Mouse
Invented by Prof Joyce Taylor-Papadimitriou from King's College London , Prof Joy Burchell from King's College London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151555 |
| Antigen/Gene or Protein Targets | Human MUC1 (mucin-like protein 1) / PEM (polymorphic epithelial mucin) |
| Disease Keywords | Cancer; adenocarcinoma; drug metabolism & toxicity |
| Synonyms | ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227 |
| Relevance | Model for preclinical study of anti-MUC1 vaccines/immunotherapies; |
| Production Details | A linear genomic fragment, containing the MUC1 gene and promoter, was injected into fertilized embryos (various backgrounds), and implanted into pseudopregnant mice. Transgenic mice were identified by Southern blot, and maintained as homozygotes. |
| Conditional Description | Genomic fragment containing complete MUC1 gene and promoter region, enabling tissue-specific MUC1 expression pattern. |
| Mouse Genetic Background/Cross History | CBA/C57BL/6 or BALBc or C57 |
| Zygosity | Homozygous |
| Research Area | Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Genetic Studies Tools |
| Notes | Mice demonstrate tissue-specific PEM expression pattern and glycosylation analogous to that observed in human tissues. |
References: 2 entries
Peat et al. 1992. Cancer Res. 52(7):1954-60. PMID: 1372533.
Tissue-specific expression of a human polymorphic epithelial mucin (MUC1) in transgenic mice.
Europe PMC ID: 1372533
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References: 2 entries
Peat et al. 1992. Cancer Res. 52(7):1954-60. PMID: 1372533.
Tissue-specific expression of a human polymorphic epithelial mucin (MUC1) in transgenic mice.
Add a reference
