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Monoclonal Antibodies

Anti-RAET1E [RAET1E 79/6]

Invented at University of Cambridge
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Adapted from Song M, Wang C, Wang H, Zhang T, Li J, Benezra R, Chouchane L, Sun YH, Cui XG, Ma X. Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response. Oncoimmunology. 2020 Apr 14;9(1):1746148. doi: 10.1080/2162402X.2020.1746148. PMID: 32363114; PMCID: PMC7185213. Potential immunogens and interacting partners controlled by UBR5. (a) Protein expression of Raet1e in WT vs. Ubr5−/- 4T1 cells treated with MG132 or not, by Western blot analysis.
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Image thumbnail for Anti-RAET1E [RAET1E 79/6]
Catalogue Number 151540
Applications ELISA FACS IF IP Fn WB
Antigen/Gene or Protein Targets RAET1E
Synonyms UL16 binding protein 4; NKG2D Ligand 4; Latel
Reactivity Human
Relevance RAET1E (Retinoic Acid Early Transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes. RAET1E and RAET1G differ from the other RAET1 proteins by having a type I membrane-spanning sequence at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a functional ligand for NKG2D, which causes lymphocyte activation resulting in the secretion of cytokines.
Host Mouse
Immunogen Recombinant protein of human RAET1E protein produced in E.coli with a N terminal 6x His tag
Positive Control Stable RAET1E cell line
Subclass IgG1 kappa
Research Area Immunology

References

There are 7 reference entries for this reagent.

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References: 7 entries

McGilvray et al. 2010. Int J Cancer. 127(6):1412-20. PMID: 20054857.

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Ohashi et al. 2010. J Biol Chem. 285(22):16408-15. PMID: 20304922.

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Cao et al. 2007. J Biol Chem. 282(26):18922-8. PMID: 17470428.

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Eagle et al. 2006. Hum Immunol. 67(3):159-69. PMID: 16698438.

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Bacon et al. 2004. J Immunol. 173(2):1078-84. PMID: 15240696.

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Chalupny et al. 2003. Biochem Biophys Res Commun. 305(1):129-35. PMID: 12732206.

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Radosavljevic et al. 2002. Genomics. 79(1):114-23. PMID: 11827464.

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References: 7 entries

McGilvray et al. 2010. Int J Cancer. 127(6):1412-20. PMID: 20054857.

View  

Ohashi et al. 2010. J Biol Chem. 285(22):16408-15. PMID: 20304922.

View  

Cao et al. 2007. J Biol Chem. 282(26):18922-8. PMID: 17470428.

View  

Eagle et al. 2006. Hum Immunol. 67(3):159-69. PMID: 16698438.

View  

Bacon et al. 2004. J Immunol. 173(2):1078-84. PMID: 15240696.

View  

Chalupny et al. 2003. Biochem Biophys Res Commun. 305(1):129-35. PMID: 12732206.

View  

Radosavljevic et al. 2002. Genomics. 79(1):114-23. PMID: 11827464.

View  

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Inventor Information

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Invented at

University of Cambridge
University of Cambridge

114 reagents listed on Ximbio