Pdgfrb-Cre Mouse
Invented by Prof Ralf H. Adams from Max Planck Society
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151534 |
| Antigen/Gene or Protein Targets | Cre recombinase under Pdgfrb promoter |
| Disease Keywords | Cancer; angiogenesis |
| Relevance | Cre expressed under Pdgfrb promoter enabling conditional recombine expression in pericytes and smooth vascular muscle cells (tissue-specific loxP knockout/knockin) |
| Production Details | A Pdgfrb-Cre transgene vector, containing a genomic Pdgfrb promoter fragment fused to Cre recombinase and a polyA sequence, was injected into fertilised 129/C57BL6 oocytes. Founder lines were backcrossed to establish transgenic lines on a mixed 129/C57BL6 background. |
| Conditional | Yes |
| Conditional Description | Pdgfrb-Cre enables conditional, pericyte and smooth vascular muscle cell knockout/knockin/transgene expression of loxP flanked genes. |
| Mouse Genetic Background/Cross History | 129/C57BL/6 |
| Research Area | Cancer, Cardiovascular, Genetic Studies Tools, Immunology |
References: 4 entries
Kogata et al. 2009. Genes Dev. 23(19):2278-83. PMID: 19797768.
Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction.
Europe PMC ID: 19797768
Foo et al. 2006. Cell. 124(1):161-73. PMID: 16413489.
Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly.
Europe PMC ID: 16413489
Add a reference
References: 4 entries
Kogata et al. 2009. Genes Dev. 23(19):2278-83. PMID: 19797768.
Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction.
Foo et al. 2006. Cell. 124(1):161-73. PMID: 16413489.
Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly.
Add a reference
