Anti-Factor VIII:c heavy chain [RFF-VIII:c/10]
Invented by Prof Alison Goodall at University College London
Anti-Factor VIII [RFF-VIII:c/8]
Invented by Prof Alison Goodall from University Of Leicester
Invented at University College London
- Datasheet
- References (10)
- Inventor Info
Info
| Catalogue Number | 151529 |
| Applications | IF Fn WB |
| Antigen/Gene or Protein Targets | Factor VIII |
| Reactivity | Human |
| Relevance | The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody binds to human FVIII:C heavy chain and inhibits its function. |
| Host | Mouse |
| Immunogen | Purified human factor VIII |
| Subclass | IgG1 kappa |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI + 10% FCS; non-adherent; subculture every 2-3 days; split 1:5 |
| Research Area | Cardiovascular |
Anti-Factor VIII:c light chain [RFF-VIII:c/5]
Invented by Prof Alison Goodall at University College London
References: 10 entries
Takase et al. 1987. Br J Haematol. 66(4):497-502. PMID: 3117089.
Production of factor VIII deficient plasma by immunodepletion using three monoclonal antibodies.
Europe PMC ID: 3117089
Goodall et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279.
Registry of monoclonal antibodies to factor VIII and von Willebrand factor. International Committee on Thrombosis and Haemostasis.
Europe PMC ID: 3937279
Rotblat et al. 1985. Biochemistry. 24(16):4294-300. PMID: 2413885.
Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies.
Europe PMC ID: 2413885
Vehar et al. 1984. Nature. 312(5992):337-42. PMID: 6438527.
Structure of human factor VIII.
Europe PMC ID: 6438527
Rotblat et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638.
Monoclonal antibodies to human procoagulant factor VIII.
Europe PMC ID: 6403638
Add a reference
References: 10 entries
Takase et al. 1987. Br J Haematol. 66(4):497-502. PMID: 3117089.
Production of factor VIII deficient plasma by immunodepletion using three monoclonal antibodies.
Goodall et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279.
Registry of monoclonal antibodies to factor VIII and von Willebrand factor. International Committee on Thrombosis and Haemostasis.
Rotblat et al. 1985. Biochemistry. 24(16):4294-300. PMID: 2413885.
Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies.
Vehar et al. 1984. Nature. 312(5992):337-42. PMID: 6438527.
Structure of human factor VIII.
Rotblat et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638.
Monoclonal antibodies to human procoagulant factor VIII.
Add a reference
Inventor Information
Inventors
|
Prof Alison Goodall |
