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Anti-HPV16 E1/E4 [TVG 401]


Catalogue Number 151522
Applications ELISA IHC WB
Antigen/Gene or Protein Targets Human Papilloma Virus 16 early proteins 1 and 4 (HPV16 E1/E4).
Reactivity Human papilloma virus
Relevance The human papilloma virus (HPV) family of DNA tumour viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. E1 and E2 are proteins involved in the regulation of viral DNA replication. The monoclonal antibodies TVG 401,TVG 402 and TVG 403 represent the first against HPV16 E1/\E4 and should complement those already available to E7 and L1 for the screening of frozen sections of clinical biopsies and will be of value in monitoring the progress of HPV infection from benign lesions to invasive cancer.
Host Mouse
Immunogen Antigen for hybridoma production was expressed as a b galactosidase fusion protein using the pEX expression system and was consequently cleaved to release the E1/\E4 polypeptide.
Subclass IgG1
Molecular Weight (kDa) 10
Myeloma Used NS0
Recommended Growing Conditions RPMI 1640 + 15% FCS
Research Area Cancer, Virology

References: 1 entry

Doorbar et al. 1992. Virology. 187(1):353-9. PMID: 1371027.

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