Jagged1 Floxed Mouse
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151482 |
| Antigen/Gene or Protein Targets | Jagged1 (Jag1) |
| Disease Keywords | Cancer; autoimmune disease |
| Relevance | Conditional knockout of Jag1; in vivo studies of tissue-specific Jag1 knockout and Notch signalling |
| Production Details | A Jag1 targeting vector, containing a loxP flanked resistance cassette before exon 4 and a loxP site inserted after exon 5, was transfected into 129 ES cells. Properly targeted ES cells containing a homologous recombination event were transfected with a Cre expression vector to excise the resistance cassette, and injected into a C57BL6 blastocyst. Chimeric offspring were mated on a C57BL6 background. |
| Conditional | Yes |
| Conditional Description | Jag1 gene with loxP sites flanking exons 4 & 5 enabling conditional Cre-mediate knockout. |
| Mouse Genetic Background/Cross History | 129/C57BL/6 |
| Zygosity | Heterozygous |
| Research Area | Cardiovascular, Cell Signaling & Signal Transduction, Genetic Studies Tools, Neurobiology |
References: 2 entries
Brooker et al. 2006. Development. 133(7):1277-86. PMID: 16495313.
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear.
Europe PMC ID: 16495313
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References: 2 entries
Brooker et al. 2006. Development. 133(7):1277-86. PMID: 16495313.
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear.
Add a reference
