p23+/- Mouse
Invented by Dr Mike Owen from Independent Pharmaceutical And Biotech Consultant
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151467 |
| Antigen/Gene or Protein Targets | p23 |
| Relevance | In vivo study of p23 knockout, golgi apparatus and early secretory pathway function |
| Production Details | A p23 targeting vector, constructed from genomic fragments, but replacing exon 1 of the p23 gene with a resistance marker, was transfected into 129 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, and injected into C57BL/6 blastocysts. Chimeric offspring were mated to C57BL/6 mice to generate mice heterozygous for the p23 knockout allele, p23+/- mice. |
| Growth/Phenotype Keywords | Golgi apparatus abnormalities |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Genetic Studies Tools, Immunology |
| Notes |
Genetic Bkg: 129/C57BL/6. Zygosity: Heterozygous |
References: 2 entries
Denzel et al. 2000. Curr Biol. 10(1):55-8. PMID: 10660306.
The p24 family member p23 is required for early embryonic development.
Europe PMC ID: 10660306
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References: 2 entries
Denzel et al. 2000. Curr Biol. 10(1):55-8. PMID: 10660306.
The p24 family member p23 is required for early embryonic development.
Add a reference
