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Anti-FBW7 [FBOX 3a9/1]

Info

Catalogue Number 151461
Applications FACS IHC IF IP WB
Antigen/Gene or Protein Targets F-box/WD repeat-containing protein 7 (FBW7, Cdc4)
Synonyms F-Box And WD Repeat Domain Containing 7; F-Box Protein FBX30; SEL-10; Fbx30; HCdc4; FBW7; Hago; Homolog Of C Elegans Sel-10; F-Box Protein SEL-10; Archipelago Homolog; F-Box Protein FBW7; Archipelago; FBXO30; FBXW6; CDC4; FBW6; AGO
Reactivity Human and Mouse
Relevance SCF (Skp, Cullin, F-box containing complex) ubiquitin ligases regulate the degradation of many proteins involved in the control of cell division and growth. F-box proteins are the SCF components that bind to substrates, and this binding is usually signaled by substrate phosphorylation. The FBW7/Cdc4 F-box protein was first recognized by its ability to bind cyclin E, and the SCF (FBW7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. FBW7 thus negatively regulates several key oncoproteins. Accordingly, FBW7 is a tumor suppressor that is mutated in a wide spectrum of human cancers, and FBW7 functions as a haplo-insufficient tumor suppressor in mice.
Host Mouse
Immunogen Synthetic peptide of human sequence
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions E4 + 5% FCS
Research Area Cancer, Protein Degradation

References: 2 entries

Tu et al. 2013. PLoS One. 8(7):e68574. PMID: 23840897.

Nateri et al. 2004. Science. 303(5662):1374-8. PMID: 14739463.


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