GSTP1GSTP2 KO Mouse
Invented by Prof Roland Wolf from University of Dundee , Dr Colin Henderson from University of Dundee
Invented at University of Dundee
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 151443 |
| Antigen/Gene or Protein Targets | Glutathione Transferase P1 and P2 (GSTP1, GSTP2) |
| Disease Keywords | Cancer; lung adenoma; drug metabolism & toxicity |
| Relevance | In vivo study of GSTP1/2 (regulator of protein synthesis/degradation) knockout in tumourigenesis, drug metabolism and toxicity; disease model for drug metabolism and toxicity; tumourigenesis model (skin, lung) (chemically induced) |
| Production Details | A Gstp1/2 targeting vector, replacing all of the Gstp1 gene and exons 6 and 7 of the Gstp2 gene with a resistance cassette, was transfected into E14Tg2a.IV ES cells. Properly targeted ES cells containing a homologous recombination event were selected, cloned, and injected into blastocysts. Chimeric mice were mated with MF1 mice to generate mice heterozygous for GSTP1/2 knockout. Heterozygous mice were interbred to generate mice homozygous for GSTP1/2 knockout. |
| Conditional | No |
| Growth/Phenotype Keywords | Tumourigenesis (lung, skin); drug metabolism; drug toxicity |
| Mouse Genetic Background/Cross History | Available on both 129/C57BL/6 and C57BL6 |
| Zygosity | Homozygous |
| Research Area | Cancer, DNA Damage and Repair, Genetic Studies Tools |
References: 8 entries
Zhou et al. 2008. Am J Respir Crit Care Med. 178(12):1202-10. PMID: 18787219.
Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.
Europe PMC ID: 18787219
Elsby et al. 2003. J Biol Chem. 278(25):22243-9. PMID: 12646564.
Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.
Europe PMC ID: 12646564
Rosario et al. 2000. Mol Pharmacol. 58(1):167-74. PMID: 10860939.
Cellular response to a glutathione S-transferase P1-1 activated prodrug.
Europe PMC ID: 10860939
Henderson et al. 1998. Proc Natl Acad Sci U S A. 95(9):5275-80. PMID: 9560266.
Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases.
Europe PMC ID: 9560266
Add a reference
References: 8 entries
Zhou et al. 2008. Am J Respir Crit Care Med. 178(12):1202-10. PMID: 18787219.
Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.
Elsby et al. 2003. J Biol Chem. 278(25):22243-9. PMID: 12646564.
Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.
Rosario et al. 2000. Mol Pharmacol. 58(1):167-74. PMID: 10860939.
Cellular response to a glutathione S-transferase P1-1 activated prodrug.
Henderson et al. 1998. Proc Natl Acad Sci U S A. 95(9):5275-80. PMID: 9560266.
Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases.
Add a reference
Inventor Information
Inventors
|
Prof Roland Wolf |
