Anti-nNav 1.5 [4G8:1G7]
Invented at Cancer Research Horizons
- Datasheet
- References (5)
- Inventor Info
Info
| Catalogue Number | 151409 |
| Applications | FACS IHC IF WB |
| Antigen/Gene or Protein Targets | Neonatal Nav1.5 (Voltage gated Sodium Channel Nav1.5) |
| Reactivity | Human |
| Relevance | Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. They have also been detected in lymphocytes, glia, and fibroblasts. VGSC proteins are comprised of a core alpha-subunit, together with one or more additional regulatoy beta-subunit. VCSC expression has been detected in a number of tumour cell lines and has been implicated in the metastatic behaviour of breast and prostate cancer cells. Na(v)1.5, the major cardiac voltage-gated Na(+) channel, plays a central role in the generation of the cardiac action potential and in the propagation of electrical impulses in the heart. Its importance for normal heart function has been recently exemplified by reports of numerous mutations found in the gene SCN5A which encodes Na(v)1.5. |
| Host | Mouse |
| Immunogen | Peptide (14mer) from an extracellular domain of Nav1.5 - VSENIKLGNLSALR |
| Positive Control | Cell lines over expressing Nav1.5, e.g Nav 1.5-HEK293 cells |
| Subclass | IgM |
| Molecular Weight (kDa) | 180-200 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | CD1 |
| Notes | 4G8:1G7 is recommended for Western blotting and Immunocytochemistry using 2ug/ml and 10ug/ml, respectively. |
| Research Area | Cellular Transport, Neurobiology |
References: 5 entries
Vikram et al. 2017. Nat Med. 23(3):361-367. PMID: 28191886.
Utrilla et al. 2017. Front Physiol. 8:903. PMID: 29184507.
Guo et al. 2011. Toxicol Sci. 123(1):281-9. PMID: 21693436.
Guo et al. 2011. Toxicol Sci. 123(1):281-9. PMID: 21693436.
Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes.
Europe PMC ID: 21693436
Add a reference
References: 5 entries
Vikram et al. 2017. Nat Med. 23(3):361-367. PMID: 28191886.
Utrilla et al. 2017. Front Physiol. 8:903. PMID: 29184507.
Guo et al. 2011. Toxicol Sci. 123(1):281-9. PMID: 21693436.
Guo et al. 2011. Toxicol Sci. 123(1):281-9. PMID: 21693436.
Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes.
Add a reference
