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Anti-BCL2 [bcl-2/124]

Invented by Dr Jacqueline Cordell at University of Oxford

Info

Catalogue Number 151407
Applications IHC WB
Antigen/Gene or Protein Targets Bcl2
Reactivity Human
Relevance The pro-survival protein BCL2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Damage to the Bcl-2 gene has been identified as a cause of a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, and a possible cause of schizophrenia and autoimmunity. It is also a cause of resistance to cancer treatments.
Host Mouse
Immunogen Synthetic peptide of amino acids 41-54 of human bcl-2 oncoprotein
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Signaling & Signal Transduction, Metabolism

References: 44 entries

Chang et al. 2016. J Formos Med Assoc. :. PMID: 27773559.

Immunophenotypic and genetic characteristics of diffuse large B-cell lymphoma in Taiwan.

Europe PMC ID: 27773559

Ishiguro et al. 2016. Hum Cell. :. PMID: 27613543.

IHC

Molecular cytogenetic characterization of two established ESFT cell lines.

Europe PMC ID: 27613543

Otali et al. 2016. Biotech Histochem. :1-18. PMID: 27149658.

IHC

A standard tissue as a control for histochemical and immunohistochemical staining.

Europe PMC ID: 27149658

Cortese et al. 2016. Neurology. :. PMID: 26843560.

Cutaneous adverse events in multiple sclerosis patients treated with daclizumab.

Europe PMC ID: 26843560

Miltiades et al. 2015. Clin Cancer Res. :. PMID: 26700206.

The Stat3/5 Signaling Biosignature in Hematopoietic Stem/Progenitor Cells Predicts Response and Outcome in Myelodysplastic Syndrome Patients Treated with Azacitidine.

Europe PMC ID: 26700206

Tajima et al. 2015. Int J Clin Exp Pathol. 8(3):3262-9. PMID: 26045850.

IHC

Pankova et al. 2015. Tumour Biol. :. PMID: 26456960.

IHC

Recurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium.

Europe PMC ID: 26456960

Miyagi Maeshima et al. 2015. J Clin Exp Hematop. 55(1):7-11. PMID: 26106000.

IHC

Primary synovial sarcoma of the right heart involving the tricuspid valve in an elderly Chinese woman: a case report.

Europe PMC ID: 26112006

Huo et al. 2015. Diagn Pathol. 10:80. PMID: 26112006.

Higashi et al. 2015. Leuk Lymphoma. :1-6. PMID: 25860238.

Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.

Europe PMC ID: 25860238

Cystic synovial sarcoma of the pleura mimicking a cystic thymoma: a case report illustrating the role of decreased INI-1 expression in differential diagnosis.

Europe PMC ID: 26045850

Histopathological Characteristics of Lymphomas in the Upper Aerodigestive Tract. A Single-Institute Study in Japan.

Europe PMC ID: 26106000

Navratil et al. 1995. J Clin Pathol. 48(1):18-21. PMID: 7706514.

Ashton-Key et al. 1995. Histopathology. 26(1):75-8. PMID: 7713486.

Heterogeneity of bcl-2 expression in MALT lymphoma.

Europe PMC ID: 7713486

Expression of the bcl-2 protein in B cell lymphomas arising from mucosa associated lymphoid tissue.

Europe PMC ID: 7706514

Piris et al. 1994. Br J Cancer. 69(2):337-41. PMID: 8297731.

p53 and bcl-2 expression in high-grade B-cell lymphomas: correlation with survival time.

Europe PMC ID: 8297731

Leek et al. 1994. Br J Cancer. 69(1):135-9. PMID: 8286195.

de Jong et al. 1994. Cancer Res. 54(1):256-60. PMID: 8261449.

Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells.

Europe PMC ID: 8261449

bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer.

Europe PMC ID: 8286195

Pezzella et al. 1993. N Engl J Med. 329(10):690-4. PMID: 8393963.

bcl-2 protein in non-small-cell lung carcinoma.

Europe PMC ID: 8393963

Doussis et al. 1993. Am J Clin Pathol. 99(6):663-7. PMID: 8322700.

An immunocytochemical study of p53 and bcl-2 protein expression in Hodgkin's disease.

Europe PMC ID: 8322700

Pezzella et al. 1993. Histopathology. 22(1):39-44. PMID: 8436340.

Immunohistochemical detection of p53 and bcl-2 proteins in non-Hodgkin's lymphoma.

Europe PMC ID: 8436340

Gaulard et al. 1992. Am J Pathol. 140(5):1089-95. PMID: 1374590.

Expression of the bcl-2 gene product in follicular lymphoma.

Europe PMC ID: 1374590

Pezzella et al. 1992. Br J Cancer. 65(1):87-9. PMID: 1733447.

Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma.

Europe PMC ID: 1733447

Pezzella et al. 1990. Lancet. 336(8729):1510-1. PMID: 1979117.

Bcl-2 protein expression in follicular lymphomas in absence of 14;18 translocation.

Europe PMC ID: 1979117

Lehmkuhl et al. 1977. Am J Vet Res. 38(11):1717-20. PMID: 201196.

Investigation of causative agents of bovine respiratory tract disease in a beef cow-calf herd with an early weaning program.

Europe PMC ID: 201196


Add a reference

References: 44 entries

Chang et al. 2016. J Formos Med Assoc. :. PMID: 27773559.

Immunophenotypic and genetic characteristics of diffuse large B-cell lymphoma in Taiwan.

Europe PMC ID: 27773559

Ishiguro et al. 2016. Hum Cell. :. PMID: 27613543.

IHC

Molecular cytogenetic characterization of two established ESFT cell lines.

Europe PMC ID: 27613543

Otali et al. 2016. Biotech Histochem. :1-18. PMID: 27149658.

IHC

A standard tissue as a control for histochemical and immunohistochemical staining.

Europe PMC ID: 27149658

Cortese et al. 2016. Neurology. :. PMID: 26843560.

Cutaneous adverse events in multiple sclerosis patients treated with daclizumab.

Europe PMC ID: 26843560

Miltiades et al. 2015. Clin Cancer Res. :. PMID: 26700206.

The Stat3/5 Signaling Biosignature in Hematopoietic Stem/Progenitor Cells Predicts Response and Outcome in Myelodysplastic Syndrome Patients Treated with Azacitidine.

Europe PMC ID: 26700206

Tajima et al. 2015. Int J Clin Exp Pathol. 8(3):3262-9. PMID: 26045850.

IHC

Pankova et al. 2015. Tumour Biol. :. PMID: 26456960.

IHC

Recurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium.

Europe PMC ID: 26456960

Miyagi Maeshima et al. 2015. J Clin Exp Hematop. 55(1):7-11. PMID: 26106000.

IHC

Primary synovial sarcoma of the right heart involving the tricuspid valve in an elderly Chinese woman: a case report.

Europe PMC ID: 26112006

Huo et al. 2015. Diagn Pathol. 10:80. PMID: 26112006.

Higashi et al. 2015. Leuk Lymphoma. :1-6. PMID: 25860238.

Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.

Europe PMC ID: 25860238

Cystic synovial sarcoma of the pleura mimicking a cystic thymoma: a case report illustrating the role of decreased INI-1 expression in differential diagnosis.

Europe PMC ID: 26045850

Histopathological Characteristics of Lymphomas in the Upper Aerodigestive Tract. A Single-Institute Study in Japan.

Europe PMC ID: 26106000

Navratil et al. 1995. J Clin Pathol. 48(1):18-21. PMID: 7706514.

Ashton-Key et al. 1995. Histopathology. 26(1):75-8. PMID: 7713486.

Heterogeneity of bcl-2 expression in MALT lymphoma.

Europe PMC ID: 7713486

Expression of the bcl-2 protein in B cell lymphomas arising from mucosa associated lymphoid tissue.

Europe PMC ID: 7706514

Piris et al. 1994. Br J Cancer. 69(2):337-41. PMID: 8297731.

p53 and bcl-2 expression in high-grade B-cell lymphomas: correlation with survival time.

Europe PMC ID: 8297731

Leek et al. 1994. Br J Cancer. 69(1):135-9. PMID: 8286195.

de Jong et al. 1994. Cancer Res. 54(1):256-60. PMID: 8261449.

Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells.

Europe PMC ID: 8261449

bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer.

Europe PMC ID: 8286195

Pezzella et al. 1993. N Engl J Med. 329(10):690-4. PMID: 8393963.

bcl-2 protein in non-small-cell lung carcinoma.

Europe PMC ID: 8393963

Doussis et al. 1993. Am J Clin Pathol. 99(6):663-7. PMID: 8322700.

An immunocytochemical study of p53 and bcl-2 protein expression in Hodgkin's disease.

Europe PMC ID: 8322700

Pezzella et al. 1993. Histopathology. 22(1):39-44. PMID: 8436340.

Immunohistochemical detection of p53 and bcl-2 proteins in non-Hodgkin's lymphoma.

Europe PMC ID: 8436340

Gaulard et al. 1992. Am J Pathol. 140(5):1089-95. PMID: 1374590.

Expression of the bcl-2 gene product in follicular lymphoma.

Europe PMC ID: 1374590

Pezzella et al. 1992. Br J Cancer. 65(1):87-9. PMID: 1733447.

Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma.

Europe PMC ID: 1733447

Pezzella et al. 1990. Lancet. 336(8729):1510-1. PMID: 1979117.

Bcl-2 protein expression in follicular lymphomas in absence of 14;18 translocation.

Europe PMC ID: 1979117

Lehmkuhl et al. 1977. Am J Vet Res. 38(11):1717-20. PMID: 201196.

Investigation of causative agents of bovine respiratory tract disease in a beef cow-calf herd with an early weaning program.

Europe PMC ID: 201196


Add a reference

References: 44 entries

Chang et al. 2016. J Formos Med Assoc. :. PMID: 27773559.

Immunophenotypic and genetic characteristics of diffuse large B-cell lymphoma in Taiwan.

Ishiguro et al. 2016. Hum Cell. :. PMID: 27613543.

IHC

Molecular cytogenetic characterization of two established ESFT cell lines.

Otali et al. 2016. Biotech Histochem. :1-18. PMID: 27149658.

IHC

A standard tissue as a control for histochemical and immunohistochemical staining.

Cortese et al. 2016. Neurology. :. PMID: 26843560.

Cutaneous adverse events in multiple sclerosis patients treated with daclizumab.

Miltiades et al. 2015. Clin Cancer Res. :. PMID: 26700206.

The Stat3/5 Signaling Biosignature in Hematopoietic Stem/Progenitor Cells Predicts Response and Outcome in Myelodysplastic Syndrome Patients Treated with Azacitidine.

Tajima et al. 2015. Int J Clin Exp Pathol. 8(3):3262-9. PMID: 26045850.

IHC

Pankova et al. 2015. Tumour Biol. :. PMID: 26456960.

IHC

Recurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium.

Miyagi Maeshima et al. 2015. J Clin Exp Hematop. 55(1):7-11. PMID: 26106000.

IHC

Primary synovial sarcoma of the right heart involving the tricuspid valve in an elderly Chinese woman: a case report.

Huo et al. 2015. Diagn Pathol. 10:80. PMID: 26112006.

Higashi et al. 2015. Leuk Lymphoma. :1-6. PMID: 25860238.

Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.

Cystic synovial sarcoma of the pleura mimicking a cystic thymoma: a case report illustrating the role of decreased INI-1 expression in differential diagnosis.

Histopathological Characteristics of Lymphomas in the Upper Aerodigestive Tract. A Single-Institute Study in Japan.

Navratil et al. 1995. J Clin Pathol. 48(1):18-21. PMID: 7706514.

Ashton-Key et al. 1995. Histopathology. 26(1):75-8. PMID: 7713486.

Heterogeneity of bcl-2 expression in MALT lymphoma.

Expression of the bcl-2 protein in B cell lymphomas arising from mucosa associated lymphoid tissue.

Piris et al. 1994. Br J Cancer. 69(2):337-41. PMID: 8297731.

p53 and bcl-2 expression in high-grade B-cell lymphomas: correlation with survival time.

Leek et al. 1994. Br J Cancer. 69(1):135-9. PMID: 8286195.

de Jong et al. 1994. Cancer Res. 54(1):256-60. PMID: 8261449.

Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells.

bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer.

Pezzella et al. 1993. N Engl J Med. 329(10):690-4. PMID: 8393963.

bcl-2 protein in non-small-cell lung carcinoma.

Doussis et al. 1993. Am J Clin Pathol. 99(6):663-7. PMID: 8322700.

An immunocytochemical study of p53 and bcl-2 protein expression in Hodgkin's disease.

Pezzella et al. 1993. Histopathology. 22(1):39-44. PMID: 8436340.

Immunohistochemical detection of p53 and bcl-2 proteins in non-Hodgkin's lymphoma.

Gaulard et al. 1992. Am J Pathol. 140(5):1089-95. PMID: 1374590.

Expression of the bcl-2 gene product in follicular lymphoma.

Pezzella et al. 1992. Br J Cancer. 65(1):87-9. PMID: 1733447.

Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma.

Pezzella et al. 1990. Lancet. 336(8729):1510-1. PMID: 1979117.

Bcl-2 protein expression in follicular lymphomas in absence of 14;18 translocation.

Lehmkuhl et al. 1977. Am J Vet Res. 38(11):1717-20. PMID: 201196.

Investigation of causative agents of bovine respiratory tract disease in a beef cow-calf herd with an early weaning program.


Add a reference


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