Anti-LILR [GHI/75]
Invented by Karen Pulford from University of Oxford
Invented at University of Oxford
- Datasheet
- References (8)
- Inventor Info
Info
![Anti-LILR [GHI/75] antibody staining transfectants to see which of the CD85 family members the antibody recognises. Image kindly provided by Giovanna Roncador, Spanish National Cancer Research Centre (CNIO).](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/e8c1ae10-a197-4cd7-b6fc-e31eb0738e22.png)
![Anti-LILR [GHI/75] antibody staining transfectants to see which of the CD85 family members the antibody recognises. Image kindly provided by Giovanna Roncador, Spanish National Cancer Research Centre (CNIO).](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/e8c1ae10-a197-4cd7-b6fc-e31eb0738e22.png)
![Image thumbnail for Anti-LILR [GHI/75]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/e8c1ae10-a197-4cd7-b6fc-e31eb0738e22.png)
| Catalogue Number | 151377 |
| Applications | FACS IHC IF IP WB |
| Antigen/Gene or Protein Targets | Leukocyte Immunogolobulin-like Receptor 1 (LILR, CD85) |
| Reactivity | Human |
| Relevance | LILR is a 120kD membrane glycoprotein expressed strongly on plasma cells, moderately on circulating B cells and weakly on monocytes. It is not expressed on neutrophils, T cells, NK cells or any non-hematopoietic cells. |
| Host | Mouse |
| Immunogen | Hairy cell leukaemia cells |
| Subclass | IgG2b |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| Notes | Ultroser G can be used at 1% if the cells are not growing well. |
| Research Area | Immunology |
References: 8 entries
Morel et al. 2008. J Immunol. 181(4):2368-81. PMID: 18684926.
HLA class I molecules regulate IFN-gamma production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j.
Europe PMC ID: 18684926
Kirwan et al. 2005. J Immunol. 175(8):5006-15. PMID: 16210603.
Killer cell Ig-like receptor-dependent signaling by Ig-like transcript 2 (ILT2/CD85j/LILRB1/LIR-1).
Europe PMC ID: 16210603
Banham et al. 1999. J Leukoc Biol. 65(6):841-5. PMID: 10380908.
Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin superfamily.
Europe PMC ID: 10380908
Pulford et al. 1991. Clin Exp Immunol. 85(3):429-35. PMID: 1893623.
A 72-kD B cell-associated surface glycoprotein expressed at high levels in hairy cell leukaemia and plasma cell neoplasms.
Europe PMC ID: 1893623
Add a reference
References: 8 entries
Morel et al. 2008. J Immunol. 181(4):2368-81. PMID: 18684926.
HLA class I molecules regulate IFN-gamma production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j.
Kirwan et al. 2005. J Immunol. 175(8):5006-15. PMID: 16210603.
Killer cell Ig-like receptor-dependent signaling by Ig-like transcript 2 (ILT2/CD85j/LILRB1/LIR-1).
Banham et al. 1999. J Leukoc Biol. 65(6):841-5. PMID: 10380908.
Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin superfamily.
Pulford et al. 1991. Clin Exp Immunol. 85(3):429-35. PMID: 1893623.
A 72-kD B cell-associated surface glycoprotein expressed at high levels in hairy cell leukaemia and plasma cell neoplasms.
Add a reference
