Anti-ATM [ATM 11G12]
Invented at University Of Birmingham
- Datasheet
- References (10)
- Inventor Info
Info
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| Catalogue Number | 151333 |
| Applications | IF IP WB |
| Antigen/Gene or Protein Targets | Ataxia Telangiesctasia Mutated (ATM) |
| Reactivity | Human |
| Relevance | The ATM protein is a member of the phosphatidylinositol-3 kinase family of proteins that respond to DNA damage by phosphorylating key substrates involved in DNA repair and/or cell cycle control. It is thought that the activation of ATM by autophosphorylation might be the initiating event of cellular responses to irradiation. The classic form of ataxia telangiectasia, an autosomal recessive cerebellar ataxia, results from the presence of two truncating ATM mutations, leading to a total loss of the ATM protein. |
| Host | Mouse |
| Immunogen | Residues 992-1144 of ATM fusion protein |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 370 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Notes | Suggested Dilution: 1:500 |
| Research Area | Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 10 entries
Dynamics of DNA damage induced pathways to cancer.
Europe PMC ID: 24023735
Tian et al. 2013. PLoS One. 8(9):e72303. PMID: 24023735.
WB
Reiman et al. 2011. Br J Cancer. 105(4):586-91. PMID: 21792198.
WB
Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours.
Europe PMC ID: 21792198
Dutton et al. 2007. Blood. 109(6):2597-603. PMID: 17148591.
Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells.
Europe PMC ID: 17148591
Clements et al. 2004. DNA Repair (Amst). 3(11):1493-502. PMID: 15380105.
IF
The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4.
Europe PMC ID: 15380105
Starczynski et al. 2003. Am J Pathol. 163(2):423-32. PMID: 12875964.
Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias.
Europe PMC ID: 12875964
Add a reference
References: 10 entries
Dynamics of DNA damage induced pathways to cancer.
Tian et al. 2013. PLoS One. 8(9):e72303. PMID: 24023735.
WB
Reiman et al. 2011. Br J Cancer. 105(4):586-91. PMID: 21792198.
WB
Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours.
Dutton et al. 2007. Blood. 109(6):2597-603. PMID: 17148591.
Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells.
Clements et al. 2004. DNA Repair (Amst). 3(11):1493-502. PMID: 15380105.
IF
The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4.
Starczynski et al. 2003. Am J Pathol. 163(2):423-32. PMID: 12875964.
Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias.
Add a reference
