Anti-Leu2 [UCH-T4]
Invented by Prof Peter Beverley from Imperial College
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (7)
- Inventor Info
Info
| Catalogue Number | 151177 |
| Applications | FACS IHC IF |
| Antigen/Gene or Protein Targets | Leu2 (CD8) |
| Reactivity | Human |
| Relevance | Leu-2 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class I molecules. Leu-2 is present on human suppressor / cytotoxic T cells, 30% of circulating T cells. UCH-T4 is recommended for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorisation of T cell acute lymphoblastic leukaemia and lymphoblastic lymphoma in conjunction with other antigens and determination of T4/T8 ratios in immune deficiencies, rheumatoid arthritis, multiple sclerosis, etc. |
| Host | Mouse |
| Immunogen | Thymocytes followed by Sezary T cells. |
| Subclass | IgG2a |
| Molecular Weight (kDa) | 32 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | Immunology, Stem Cell Biology |
References: 7 entries
Beverley P. 1982. Proc. Royal Soc. Edin. 81B:221-232
Waleh et al. 2011. Pediatr Res. 70(4):332-8. PMID: 21691249.
Anatomic closure of the premature patent ductus arteriosus: The role of CD14+/CD163+ mononuclear cells and VEGF in neointimal mound formation.
Europe PMC ID: 21691249
Martín et al. 2002. J Cutan Pathol. 29(6):347-53. PMID: 12135465.
Vascular endothelium express CS-1 fibronectin in allergic contact dermatitis.
Europe PMC ID: 12135465
Kee et al. 2000. J Cell Biochem. 78(1):97-111. PMID: 10797569.
beta1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum.
Europe PMC ID: 10797569
Add a reference
References: 7 entries
Beverley P. 1982. Proc. Royal Soc. Edin. 81B:221-232
Waleh et al. 2011. Pediatr Res. 70(4):332-8. PMID: 21691249.
Anatomic closure of the premature patent ductus arteriosus: The role of CD14+/CD163+ mononuclear cells and VEGF in neointimal mound formation.
Martín et al. 2002. J Cutan Pathol. 29(6):347-53. PMID: 12135465.
Vascular endothelium express CS-1 fibronectin in allergic contact dermatitis.
Kee et al. 2000. J Cell Biochem. 78(1):97-111. PMID: 10797569.
beta1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum.
Add a reference
