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Monoclonal Antibodies

Anti-HPV16E7 [TVG 701Y]

Invented at University of Cambridge
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Image thumbnail for Anti-HPV16E7 [TVG 701Y]
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Adapted from Kannan et al. 2017. Sci Rep; 7:46102. PMID: 28383029. Figure. Histopathological analysis of the normal and cancer tissues by Hematoxylene and Eosine staining. HPV-16-E7 protein was detected (arrowheads) by immunohistochemistry. Image magnification X 200.
Adapted from Kannan et al. 2017. Sci Rep; 7:46102. PMID: 28383029. Figure. Detection of HPV-16-E7, MUC-16 and SIRPA expression in the circulating exosomes of 7 additional HPVOPC cases (HN1-HN7). The expression of HPV-16-E7, MUC-16 and SIRPA was undetectable in the circulating exosomes obtained from cancer-free healthy individual UM-SCC-104, a HPVOPC patient derived aggressive cell line was used as a positive control for HPV-16-E7 integration. Syntenin was used as an exosome marker.
Harris et al. 2013. Br J Cancer. 108(4):859-65. PMID: 23385729. Figure. Immunohistochemical evaluation of E6 and E7 oncogenes expression in RIT-treated CasKi and 2A3 cells. (A) E6 in CasKi cells, (B) E7 in CasKi cells; (C) E6 in 2A3 cells; (D) E7 in 2A3 cells. Left panels show untreated cells and right panels RIT-treated cells. Cells positive for E6 and E7 oncogenes stained brown. Original magnification × 400
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Catalogue Number 151170
Applications ELISA IHC IF WB
Antigen/Gene or Protein Targets Human Papilloma Virus-16 early protein 7 (HPV16 E7)
Reactivity Human papilloma virus
Relevance The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively.
Host Mouse
Immunogen HPV 16 E7 synthesised from S. pombe
Subclass IgG2a
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 15% FCS.
Strain Balb/c
Research Area Cancer, Virology

References

There are 6 reference entries for this reagent.

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References: 6 entries

Chen et al. 2020. Antiviral Res. 178:104794. PMID: 32298665.

WB

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Kannan et al. 2017. Sci Rep. 7:46102. PMID: 28383029.

IHC WB

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Harris et al. 2013. Br J Cancer. 108(4):859-65. PMID: 23385729.

IHC

View  

Combined treatment of the experimental human papilloma virus-16-positive cervical and head and neck cancers with cisplatin and radioimmunotherapy targeting viral E6 oncoprotein.

Europe PMC ID: 23385729

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Tommasino et al. 1993. Oncogene. 8(1):195-202. PMID: 8380917.

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HPV16 E7 protein associates with the protein kinase p33CDK2 and cyclin A.

Europe PMC ID: 8380917

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Add a reference

References: 6 entries

Chen et al. 2020. Antiviral Res. 178:104794. PMID: 32298665.

WB

View  

Kannan et al. 2017. Sci Rep. 7:46102. PMID: 28383029.

IHC WB

View  

Harris et al. 2013. Br J Cancer. 108(4):859-65. PMID: 23385729.

IHC

View  

Combined treatment of the experimental human papilloma virus-16-positive cervical and head and neck cancers with cisplatin and radioimmunotherapy targeting viral E6 oncoprotein.

View  

Tommasino et al. 1993. Oncogene. 8(1):195-202. PMID: 8380917.

View  

HPV16 E7 protein associates with the protein kinase p33CDK2 and cyclin A.

View  

Add a reference

Inventor Information

No inventors are currently linked to this reagent.

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Invented at

University of Cambridge
University of Cambridge

114 reagents listed on Ximbio