Anti-EGFR [F4]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (8)
- Inventor Info
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| Catalogue Number | 151097 |
| Applications | ELISA FACS IHC IP RIA |
| Antigen/Gene or Protein Targets | Epidermal Growth Factor Receptor (EGFR, Her1) |
| Reactivity | Human |
| Relevance | The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). Dysregulation of EGFR signaling as a consequence of overexpression, amplification and mutation of the EGFR gene occurs frequently in several types of cancers and many become dependent on EGFR signaling to maintain their malignant phenotypes. |
| Host | Mouse |
| Immunogen | Synthetic peptide (residues 985 to 996 of human EGFR) coupled to keyhole limpet hemocyanin. |
| Subclass | IgG1 kappa |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 5% FCS |
| Strain | Balb/c |
| Research Area | Cancer, Cell Signaling & Signal Transduction |
References: 8 entries
Jaganathan et al. 2011. PLoS One. 6(5):e19605. PMID: 21573184.
A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells.
Europe PMC ID: 21573184
Gibson et al. 2009. PLoS One. 4(9):e7222. PMID: 19787046.
Roles of specific membrane lipid domains in EGF receptor activation and cell adhesion molecule stabilization in a developing olfactory system.
Europe PMC ID: 19787046
Berger et al. 1987. J Pathol. 152(4):297-307. PMID: 3668732.
Epidermal growth factor receptors in lung tumours.
Europe PMC ID: 3668732
Gullick et al. 1986. Cancer Res. 46(1):285-92. PMID: 2998607.
Expression of epidermal growth factor receptors on human cervical, ovarian, and vulval carcinomas.
Europe PMC ID: 2998607
Add a reference
References: 8 entries
Jaganathan et al. 2011. PLoS One. 6(5):e19605. PMID: 21573184.
A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells.
Gibson et al. 2009. PLoS One. 4(9):e7222. PMID: 19787046.
Roles of specific membrane lipid domains in EGF receptor activation and cell adhesion molecule stabilization in a developing olfactory system.
Berger et al. 1987. J Pathol. 152(4):297-307. PMID: 3668732.
Epidermal growth factor receptors in lung tumours.
Gullick et al. 1986. Cancer Res. 46(1):285-92. PMID: 2998607.
Expression of epidermal growth factor receptors on human cervical, ovarian, and vulval carcinomas.
Add a reference
