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Monoclonal Antibodies

Anti-HPV16E6 & HPV18E6 [C1P5]

Invented by Dr Lawrence Banks from International Centre For Genetic Engineering And Biotechnology (ICGEB)
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
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Catalogue Number 151083
Applications IHC IP WB
Antigen/Gene or Protein Targets Human Papilloma Virus-16 and 18 early protein 6 (HPV16E6 & HPV18 E6)
Reactivity Human papilloma virus
Relevance The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. C1P5 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
Host Mouse
Immunogen Gel-purified HPV-18 E6-beta galactosidase fusion protein
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Reacts with HPV infected human cells

Stains nuclear, cytoplasmic and membrane locations. Lawson et al., 2009 show examples of IHC results.
Research Area Cancer, Virology

References

There are 10 reference entries for this reagent.

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References: 10 entries

Xie et al. 2014. Oncogene. 33(8):1037-46. PMID: 23474763.

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Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma.

Europe PMC ID: 23474763

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Herfs et al. 2012. Proc Natl Acad Sci U S A. 109(26):10516-21. PMID: 22689991.

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A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.

Europe PMC ID: 22689991

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Lawson et al. 2009. Br J Cancer. 101(8):1351-6. PMID: 19773762.

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Koilocytes indicate a role for human papilloma virus in breast cancer.

Europe PMC ID: 19773762

View  

Zhang et al. 2005. J Biol Chem. 280(39):33165-77. PMID: 15983032.

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BRCA1 interaction with human papillomavirus oncoproteins.

Europe PMC ID: 15983032

View  

Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.

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Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.

Europe PMC ID: 3033140

View  

Add a reference

References: 10 entries

Xie et al. 2014. Oncogene. 33(8):1037-46. PMID: 23474763.

View  

Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma.

View  

Herfs et al. 2012. Proc Natl Acad Sci U S A. 109(26):10516-21. PMID: 22689991.

View  

A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.

View  

Lawson et al. 2009. Br J Cancer. 101(8):1351-6. PMID: 19773762.

View  

Koilocytes indicate a role for human papilloma virus in breast cancer.

View  

Zhang et al. 2005. J Biol Chem. 280(39):33165-77. PMID: 15983032.

View  

BRCA1 interaction with human papillomavirus oncoproteins.

View  

Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.

View  

Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.

View  

Add a reference

Inventor Information