Anti-PTPRC [C11]
Invented by Prof Peter Beverley from Imperial College
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151082 |
| Applications | IHC IP |
| Antigen/Gene or Protein Targets | Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45) |
| Reactivity | Human |
| Relevance | PTPRC is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). C11 may be used for differential diagnosis of lymphoma and carcinoma and identification of haemopoietic tumours. |
| Host | Mouse |
| Immunogen | Human lymphocytes |
| Subclass | IgG2a |
| Molecular Weight (kDa) | 180-222 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | Cardiovascular, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Neurobiology, Stem Cell Biology |
References: 2 entries
Williams et al. 2003. Clin Exp Immunol. 131(1):68-74. PMID: 12519388.
Dipeptidyl peptidase IV on activated T cells as a target molecule for therapy of rheumatoid arthritis.
Europe PMC ID: 12519388
Add a reference
References: 2 entries
Williams et al. 2003. Clin Exp Immunol. 131(1):68-74. PMID: 12519388.
Dipeptidyl peptidase IV on activated T cells as a target molecule for therapy of rheumatoid arthritis.
Add a reference
