Anti-Keratin19 [BA17]
Invented by Prof Joyce Taylor-Papadimitriou from King's College London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (12)
- Inventor Info
Info
| Catalogue Number | 151077 |
| Applications | FACS IHC IP WB |
| Antigen/Gene or Protein Targets | Keratin 19 |
| Reactivity | Human |
| Relevance | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 19 (a cytokeratin) is the smallest human keratin and is found in many simple and some non-keratinising stratified squamous epithelia. The degree of keratin 19 positivity in breast cancer distinguishes malignant from benign tumours. Keratin 19 is often co-expressed with keratin 7. |
| Host | Mouse |
| Immunogen | Detergent-insoluble extract of human mammary epithelial organoids. |
| Subclass | IgG1 |
| Myeloma Used | P3X63Ag8.653 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | Cell Signaling & Signal Transduction |
References: 12 entries
Morton et al. 2008. Am J Pathol. 172(4):1081-7. PMID: 18310506.
Trp53 deletion stimulates the formation of metastatic pancreatic tumors.
Europe PMC ID: 18310506
Aleksic et al. 2007. Gut. 56(2):227-36. PMID: 16870717.
Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2.
Europe PMC ID: 16870717
Nightingale et al. 2004. J Am Soc Nephrol. 15(1):21-32. PMID: 14694154.
Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cell-myofibroblast transdifferentiation via Jak/Stat pathway activation.
Europe PMC ID: 14694154
Bártek et al. 1986. Eur J Cancer Clin Oncol. 22(12):1441-52. PMID: 2439341.
Expression of monoclonal antibody-defined epitopes of keratin 19 in human tumours and cultured cells.
Europe PMC ID: 2439341
Bartek et al. 1985. Int J Cancer. 36(3):299-306. PMID: 2411673.
Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours.
Europe PMC ID: 2411673
Bartek et al. 1985. J Cell Sci. 75:17-33. PMID: 2413060.
A subclass of luminal epithelial cells in the human mammary gland, defined by antibodies to cytokeratins.
Europe PMC ID: 2413060
Add a reference
References: 12 entries
Morton et al. 2008. Am J Pathol. 172(4):1081-7. PMID: 18310506.
Trp53 deletion stimulates the formation of metastatic pancreatic tumors.
Aleksic et al. 2007. Gut. 56(2):227-36. PMID: 16870717.
Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2.
Nightingale et al. 2004. J Am Soc Nephrol. 15(1):21-32. PMID: 14694154.
Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cell-myofibroblast transdifferentiation via Jak/Stat pathway activation.
Bártek et al. 1986. Eur J Cancer Clin Oncol. 22(12):1441-52. PMID: 2439341.
Expression of monoclonal antibody-defined epitopes of keratin 19 in human tumours and cultured cells.
Bartek et al. 1985. Int J Cancer. 36(3):299-306. PMID: 2411673.
Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours.
Bartek et al. 1985. J Cell Sci. 75:17-33. PMID: 2413060.
A subclass of luminal epithelial cells in the human mammary gland, defined by antibodies to cytokeratins.
Add a reference
