Anti-Keratin19 [BA16]
Invented by Prof Joyce Taylor-Papadimitriou from King's College London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151076 |
| Applications | FACS IHC IF WB |
| Antigen/Gene or Protein Targets | Keratin 19 |
| Reactivity | Human |
| Relevance | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 19 (a cytokeratin) is the smallest human keratin and is found in many simple and some non-keratinising stratified squamous epithelia. The degree of keratin 19 positivity in breast cancer distinguishes malignant from benign tumours. Keratin 19 is often co-expressed with keratin 7. |
| Host | Mouse |
| Immunogen | Detergent-insoluble extract of human mammary epithelial organoids. |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 40 |
| Myeloma Used | P3X63Ag8.653 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | Cell Signaling & Signal Transduction |
References: 4 entries
Bartek et al. 1985. Int J Cancer. 36(3):299-306. PMID: 2411673.
Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours.
Europe PMC ID: 2411673
Bartek et al. 1985. J Cell Sci. 75:17-33. PMID: 2413060.
A subclass of luminal epithelial cells in the human mammary gland, defined by antibodies to cytokeratins.
Europe PMC ID: 2413060
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References: 4 entries
Bartek et al. 1985. Int J Cancer. 36(3):299-306. PMID: 2411673.
Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours.
Bartek et al. 1985. J Cell Sci. 75:17-33. PMID: 2413060.
A subclass of luminal epithelial cells in the human mammary gland, defined by antibodies to cytokeratins.
Add a reference
