Anti-Alkaline phosphatase [AAP1]
Invented by Prof Walter Bodmer from University of Oxford
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (4)
- Inventor Info
Info
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| Catalogue Number | 151071 |
| Applications | ELISA WB |
| Antigen/Gene or Protein Targets | Alkaline phosphatase |
| Reactivity | Human |
| Relevance | Alkaline phosphatases are phosphodiesterases which remove phosphate groups from the 5' end of DNA, RNA and proteins at high pH. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer. |
| Host | Mouse |
| Immunogen | D98/AH-2 (HeLa) cells, which produce human intestinal alkaline phosphatase ectopically |
| Subclass | IgG2a |
| Myeloma Used | P3X63Ag8 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes | AAP.1 may be used in the diagnosis of tumours as some tumours produce intestinal ALP ectopically. |
| Research Area | Cancer, Cell Cycle, Cell Type or Organelle Marker |
References: 4 entries
Brock et al. 1985. Lancet. 1(8439):1175-8. PMID: 2860384.
Prospective prenatal diagnosis of cystic fibrosis.
Europe PMC ID: 2860384
Arklie et al. 1981. Tissue Antigens. 17(3):303-12. PMID: 7314066.
WB
A monoclonal antibody to intestinal alkaline phosphatase made against D98/AH-2 (HeLa) cells.
Europe PMC ID: 7314066
Add a reference
References: 4 entries
Brock et al. 1985. Lancet. 1(8439):1175-8. PMID: 2860384.
Prospective prenatal diagnosis of cystic fibrosis.
Arklie et al. 1981. Tissue Antigens. 17(3):303-12. PMID: 7314066.
WB
A monoclonal antibody to intestinal alkaline phosphatase made against D98/AH-2 (HeLa) cells.
Add a reference
