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Anti-Cytochrome P450 2B1, 2B2 [b/e3]

Invented by Prof Roland Wolf at University of Dundee

Info

Catalogue Number 151064
Applications ELISA IP WB
Antigen/Gene or Protein Targets Cytochromes P450 2B1, 2B2, CYP2B1, CYP2B2
Reactivity Mouse and Rat
Relevance The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. CYP2B1 and CYP2B2 are the major phenobarbital-inducible rat hepatic cytochromes P450s.
Host Mouse
Immunogen Rat liver cytochromes p450 2B1 and 2B2
Subclass IgG1
Molecular Weight (kDa) 52
Recommended Growing Conditions DMEM + 5% FCS
Notes Clone b/e3 inhibits PROD activity in liver microsomes of PB-treated rats and inhibits ECOD activity in liver microsomes of PB-treated but not 3MC-treated rats. The CYP2B1 antibody recognises the major barbiturate-inducible P450s in mouse and rat.
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism

References: 4 entries

Rencurel et al. 2005. J Biol Chem. 280(6):4367-73. PMID: 15572372.

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.

Europe PMC ID: 15572372

Forrester et al. 1992. Biochem J. 281 ( Pt 2):359-68. PMID: 1736885.

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.

Europe PMC ID: 1736885


Add a reference

References: 4 entries

Rencurel et al. 2005. J Biol Chem. 280(6):4367-73. PMID: 15572372.

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.

Europe PMC ID: 15572372

Forrester et al. 1992. Biochem J. 281 ( Pt 2):359-68. PMID: 1736885.

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.

Europe PMC ID: 1736885


Add a reference

References: 4 entries

Rencurel et al. 2005. J Biol Chem. 280(6):4367-73. PMID: 15572372.

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.

Forrester et al. 1992. Biochem J. 281 ( Pt 2):359-68. PMID: 1736885.

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.


Add a reference


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