Log in Register

Anti-Cytochrome P450 2B1, 2B2 [b/e3]


Catalogue Number 151064
Applications ELISA IP WB
Antigen/Gene or Protein Targets Cytochromes P450 2B1, 2B2, CYP2B1, CYP2B2
Reactivity Mouse and Rat
Relevance The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. CYP2B1 and CYP2B2 are the major phenobarbital-inducible rat hepatic cytochromes P450s.
Host Mouse
Immunogen Rat liver cytochromes p450 2B1 and 2B2
Subclass IgG1
Molecular Weight (kDa) 52
Recommended Growing Conditions DMEM + 5% FCS
Notes Clone b/e3 inhibits PROD activity in liver microsomes of PB-treated rats and inhibits ECOD activity in liver microsomes of PB-treated but not 3MC-treated rats. The CYP2B1 antibody recognises the major barbiturate-inducible P450s in mouse and rat.
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism

References: 2 entries

Rencurel et al. 2005. J Biol Chem. 280(6):4367-73. PMID: 15572372.

Forrester et al. 1992. Biochem J. 281 ( Pt 2):359-68. PMID: 1736885.

Add a reference

This reagent does not have any reviews at the moment.