Anti-XPA [5A2]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 151058 |
| Applications | ELISA WB |
| Antigen/Gene or Protein Targets | XPA |
| Reactivity | Human |
| Relevance | XPA binds to the Replication Protein A (RPA) and is a core component of the nucleotide excision repair pathway. XPA is involved in one of the complementation groups of the heritable condition Xeroderma pigmentosum, where defects in nucleotide excision repair result in increased susceptibility to mutagens including UV. |
| Host | Mouse |
| Immunogen | HIS-tagged recombinant human XPA protein. |
| Positive Control | LS174T, MCF-7 cells or human tonsil |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 40 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 6 entries
Wei et al. 2005. Cancer Epidemiol Biomarkers Prev. 14(8):1961-6. PMID: 16103444.
Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck.
Europe PMC ID: 16103444
Welsh et al. 2004. Int J Cancer. 110(3):352-61. PMID: 15095299.
Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines.
Europe PMC ID: 15095299
Köberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455.
Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.
Europe PMC ID: 10074455
Add a reference
References: 6 entries
Wei et al. 2005. Cancer Epidemiol Biomarkers Prev. 14(8):1961-6. PMID: 16103444.
Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck.
Welsh et al. 2004. Int J Cancer. 110(3):352-61. PMID: 15095299.
Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines.
Köberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455.
Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.
Add a reference
