Anti-Macrophage marker [5/9]
Invented at Queen Mary University of London
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151057 |
| Applications | IHC |
| Antigen/Gene or Protein Targets | Macrophage marker |
| Reactivity | Human |
| Relevance |
Monoclonal antibody capable of detecting osteoclasts and macrophages. Background and Research Application Macrophages are comprised of many forms of mononuclear phagocytes found in tissues. Mononuclear phagocytes arise from hematopoietic stem cells in the bone marrow. Functions of macrophages include non-specific phagocytosis and pinocytosis, specific phagocytosis of opsonized microorganisms mediated by Fc receptors and complement receptors. They also assist with the killing of ingested microorganisms, digestion and presentation of antigens to T and B lymphocytes, and secretion of enzymes and regulatory molecules. Antibody 5/9 may be used as a macrophage cell marker. The antigen is present in osteoclasts and 5/9 may be useful for the identification of osteoclasts in tissues relevant to developmental pathobiology. |
| Host | Mouse |
| Immunogen | A cell suspension containing osteoclasts from osteoclastomas. |
| Subclass | IgG1 |
| Myeloma Used | P3X63Ag8.653 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Concentration 1mg/ml as standard |
| Research Area | Cell Type or Organelle Marker, Immunology |
References: 2 entries
Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.
Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.
Europe PMC ID: 4053038
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References: 2 entries
Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.
Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.
Add a reference
