Anti-ICAM1 [15.2]
Invented by Prof Nancy Hogg from Cancer Research UK London Research Institute: Lincoln's Inn Fields
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (14)
- Inventor Info
Info
| Catalogue Number | 151036 |
| Applications | FACS IHC IP Fn |
| Antigen/Gene or Protein Targets | ICAM1 (CD54) |
| Synonyms | Intercellular Adhesion Molecule 1; Major Group Rhinovirus Receptor; ICAM-1; Cell Surface Glycoprotein P3.58; Human Rhinovirus Receptor; P3.58; CD54; BB2 |
| Reactivity | Human |
| Relevance | ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). |
| Host | Mouse |
| Immunogen | Rheumatoid synovial cells and human monocytes. |
| Positive Control | Tonsil |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 85-115 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | E4 +10% FCS |
| Strain | Balb/c |
| Research Area | Adhesion, Cardiovascular, Immunology, Stem Cell Biology |
References: 14 entries
Vásquez et al. 2016. Microbes Infect. :. PMID: 27717894.
Plasmodium falciparum isolates from patients with uncomplicated malaria promote endothelial inflammation.
Europe PMC ID: 27717894
Intercellular adhesion molecule 1 serves as a primary cognate receptor for the Type IV pilus of nontypeable Haemophilus influenzae.
Europe PMC ID: 26857242
Novotny et al. 2016. Cell Microbiol. :. PMID: 26857242.
Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis.
Europe PMC ID: 20977750
El-Bikai et al. 2010. Arthritis Res Ther. 12(5):R201. PMID: 20977750.
Conway et al. 2010. Am J Physiol Heart Circ Physiol. 298(2):H367-74. PMID: 19915176.
Endothelial cell responses to atheroprone flow are driven by two separate flow components: low time-average shear stress and fluid flow reversal.
Europe PMC ID: 19915176
Lauriello et al. 2005. Acta Otorhinolaryngol Ital. 25(5):284-91. PMID: 16602327.
A two-year course of specific immunotherapy or of continuous antihistamine treatment reverse eosinophilic inflammation in severe persistent allergic rhinitis.
Europe PMC ID: 16602327
Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349.
The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain.
Europe PMC ID: 10998349
Dransfield et al. 1992. J Cell Biol. 116(6):1527-35. PMID: 1541641.
Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.
Europe PMC ID: 1541641
Add a reference
References: 14 entries
Vásquez et al. 2016. Microbes Infect. :. PMID: 27717894.
Plasmodium falciparum isolates from patients with uncomplicated malaria promote endothelial inflammation.
Intercellular adhesion molecule 1 serves as a primary cognate receptor for the Type IV pilus of nontypeable Haemophilus influenzae.
Novotny et al. 2016. Cell Microbiol. :. PMID: 26857242.
Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis.
El-Bikai et al. 2010. Arthritis Res Ther. 12(5):R201. PMID: 20977750.
Conway et al. 2010. Am J Physiol Heart Circ Physiol. 298(2):H367-74. PMID: 19915176.
Endothelial cell responses to atheroprone flow are driven by two separate flow components: low time-average shear stress and fluid flow reversal.
Lauriello et al. 2005. Acta Otorhinolaryngol Ital. 25(5):284-91. PMID: 16602327.
A two-year course of specific immunotherapy or of continuous antihistamine treatment reverse eosinophilic inflammation in severe persistent allergic rhinitis.
Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349.
The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain.
Dransfield et al. 1992. J Cell Biol. 116(6):1527-35. PMID: 1541641.
Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.
Add a reference
