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Anti-Integrin aV [13C2]


Catalogue Number 151032
Applications FACS IHC IP
Antigen/Gene or Protein Targets Integrin alpha V (CD51)
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V associates with integrin beta3 to form the osteoclast functional antigen (vitronectin receptor). Integrin alpha V is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin alpha V increases with melanoma progression.
Host Mouse
Immunogen A cell suspension containing osteoclasts from osteoclastomas.
Subclass IgG1
Myeloma Used P3X63Ag8
Recommended Growing Conditions DMEM + 5% FCS.
Strain Balb/c
Research Area Stem Cell Biology

References: 3 entries

Henning et al. 2005. Gene Ther. 12(3):211-24. PMID: 15510176.

Levy et al. 2000. Mol Biol Cell. 11(2):453-66. PMID: 10679006.

Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.

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