Anti-CyclinA [E72.1]
Invented by Julian Gannon from The Francis Crick Institute
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151016 |
| Applications | IHC IF IP WB |
| Antigen/Gene or Protein Targets | Cyclin A |
| Synonyms | CCNA1; Cyclin A1; Testicular Tissue Protein Li 34; CT146 |
| Reactivity | Bovine |
| Relevance | Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. Cyclin A is a marker for actively proliferating cells and for cells in S phase. |
| Host | Mouse |
| Immunogen | Bovine Cyclin A |
| Subclass | IgG1 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Notes |
E72.1 has been used to co-immunoprecipitates CIP-1 in active trimeric complexes of cyclinA cdk-CIP-1. E72.1 is not recommended for use on parrafin embedded specimens. |
| Research Area | Cancer, Cell Cycle, Epigenetics & Nuclear Signalling |
References: 4 entries
Garner et al. 2002. Oncogene. 21(53):8089-104. PMID: 12444545.
Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint.
Europe PMC ID: 12444545
Bashir et al. 2000. Proc Natl Acad Sci U S A. 97(10):5522-7. PMID: 10792046.
Cyclin A activates the DNA polymerase delta -dependent elongation machinery in vitro: A parvovirus DNA replication model.
Europe PMC ID: 10792046
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References: 4 entries
Garner et al. 2002. Oncogene. 21(53):8089-104. PMID: 12444545.
Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint.
Bashir et al. 2000. Proc Natl Acad Sci U S A. 97(10):5522-7. PMID: 10792046.
Cyclin A activates the DNA polymerase delta -dependent elongation machinery in vitro: A parvovirus DNA replication model.
Add a reference
